| Replication dynamics of the yeast genome. |
|
M K Raghuraman, E A Winzeler, D Collingwood, S Hunt, L Wodicka, A Conway, D J Lockhart, R W Davis, B J Brewer, W L Fangman |
|
|
Science (2001), 294(5540):115-21 |
|
| Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae. The times of replication of thousands of sites across the genome were determined by hybridizing replicated and unreplicated DNAs, isolated at different times in S phase, to the microarrays. Origin activations take place continuously throughout S phase but with most firings near mid-S phase. Rates of replication fork movement vary greatly from region to region in the genome. The two ends of each of the 16 chromosomes are highly correlated in their times of replication. This microarray approach is readily applicable to other organisms, including humans. |
OriDB annotation of this paper:
|
Origin site(s) analysed by ARS assay:
|
None curated. |
Origin site(s) analysed by 2D gel analysis: |
ARS1010, ARS1018, ARS1019. |
Predicted ACS element: |
None curated. |
Experimentally confirmed ACS element: |
None curated. |
Activation ('firing') time determined: |
ARS102.5, ARS at I-102, ARS108, ARS at I-166, ARS at I-172, ARS110, ARS202, ARS207.5, ARS at II-229, ARS211, ARS216, ARS at II-551, ARS220, ARS223, ARS at II-732, ARS225, ARS227, ARS305, ARS306, ARS at III-85, ARS307, ARS308, ARS310, ARS at III-193, ARS313, ARS314, ARS at , ARS314.5, ARS at III-224, ARS315, ARS316, ARS404, ARS406, ARS409.5, ARS413, ARS416, ARS417, ARS418, ARS420, ARS422, ARS422.5, ARS423, ARS at IV-865, ARS428, ARS429, ARS430, ARS431, ARS431.5, ARS432, ARS at , ARS432.5, ARS433, ARS at , ARS435, ARS at IV-1306, ARS at IV-1380, ARS at IV-1385, ARS441, ARS at IV-1455, ARS446, ARS at , ARS at , ARS507, ARS508, ARS510, ARS511, ARS512, ARS at V-317, ARS516, ARS517, ARS518, ARS519, ARS520, ARS601, ARS601, ARS at , ARS603, ARS603.5, ARS604, ARS606, ARS607, ARS at VII-8, ARS at VII-17, ARS702, ARS at VII-70, ARS704, ARS at VII-115, ARS706, ARS707, ARS at VII-167, ARS710, ARS714, ARS at VII-288, ARS716, ARS717, ARS718, ARS719, ARS721, ARS at VII-654, ARS727, ARS728, ARS729, ARS731, ARS731.5, ARS733, ARS805, ARS815, ARS at VIII-360, ARS at VIII-367, ARS at VIII-381, ARS at , ARS818, ARS820, ARS822, ARS at VIII-505, ARS823.5, ARS at IX-34, ARS907, ARS at , ARS909, ARS at IX-205, ARS913, ARS at IX-220, ARS at IX-283, ARS920, ARS at IX-363, ARS922, ARS1005, ARS1007, ARS1007.5, ARS1009, ARS1010, ARS at X-305, ARS1012, ARS1013, ARS1014, ARS1018, ARS1019, ARS1021, ARS1103, ARS1104.5, ARS at , ARS1106, ARS1106.7, ARS at XI-257, ARS at XI-302, ARS1113, ARS1114, ARS1114.5, ARS1116, ARS at XI-584, ARS1120, ARS at XI-617, ARS at XI-633, ARS1123, ARS at XII-31, ARS1206, ARS at XII-187, ARS1210, ARS1211, ARS1212, ARS at XII-294, ARS1213, ARS1215, ARS1217, ARS at XII-599, ARS1218, ARS at , ARS1220, ARS1223, ARS at XII-749, ARS1226, ARS1227.5, ARS at XII-928, ARS at XII-931, ARS at , ARS at XII-975, ARS1232, ARS1303, ARS1304, ARS1305, ARS1307, ARS1308, ARS1310, ARS at XIII-290, ARS1312, ARS at XIII-373, ARS at XIII-433, ARS1319, ARS1325, ARS1330, ARS1332, ARS1407, ARS at XIV-159, ARS at XIV-180, ARS1412, ARS at , ARS1414, ARS1415, ARS at XIV-325, ARS1417, ARS at XIV-417, ARS at XIV-459, ARS at XIV-516, ARS1422, ARS at XIV-568, ARS1424, ARS at XIV-617, ARS1427, ARS at , ARS at , ARS1509, ARS1510, ARS1510.5, ARS1511, ARS1513, ARS1513.5, ARS at XV-459, ARS at XV-464, ARS1514, ARS at XV-495, ARS1516, ARS at , ARS1517, ARS at XV-605, ARS at XV-737, ARS1523, ARS at XV-902, ARS1528, ARS at , ARS1529, ARS at XV-1011, ARS1529.5, ARS1605, ARS1607, ARS at XVI-191, ARS1614, ARS at XVI-332, ARS1618, ARS1618.5, ARS1619, ARS at XVI-423, ARS1621, ARS at XVI-553, ARS at XVI-560, ARS1622, ARS1622.5, ARS1623, ARS1624, ARS at XVI-691, ARS1625, ARS1626.5, ARS1627, ARS at XVI-873, ARS1631, ARS at , ARS at XVI-942, ARS106, ARS at , ARS at III-146, ARS405, ARS at , ARS at IV-167, ARS434, ARS at , ARS437, ARS at IV-1356, ARS522, ARS809, ARS at VIII-261, ARS at X-212, ARS1011, ARS1020, ARS1109, ARS at XII-71, ARS at XII-77, ARS at XIII-58, ARS1309, ARS1323, ARS at XIII-727, ARS1327, ARS at XIII-763, ARS at XIII-786, ARS at , ARS at XV-855, ARS1601, ARS1602, ARS at XVI-19, ARS at XVI-91, ARS at XVI-179, ARS at , ARS1609, ARS at XVI-215, ARS203, ARS at II-96, ARS at II-100, ARS214, ARS221.5, ARS at V-256, ARS734, ARS at VII-1002, ARS at VIII-116, ARS813, ARS1008, ARS1112, ARS at XII-140, ARS1316, ARS at XIII-478, ARS1508, ARS at XV-699, ARS425, ARS at V-302, ARS605, ARS at VIII-403, ARS1004, ARS1017.5, ARS at XII-434, ARS at XVI-440, ARS105, ARS228, ARS at , ARS229, ARS409, ARS414, ARS417.5, ARS at IV-791, ARS at IV-820, ARS at IV-1524, ARS807, ARS at VIII-135, ARS at , ARS810, ARS at VIII-219, ARS at , ARS916, ARS at IX-314, ARS at XII-856, ARS1413, ARS1526, ARS at XV-947, ARS at , ARS at XVI-163, ARS at XVI-489, ARS1628, ARS at , ARS at III-308, ARS at IV-739, ARS600.3, ARS600.4, ARS at VI-236, ARS at VIII-46, ARS1016, ARS1017, ARS at X-485, ARS1022, ARS at , ARS1024, ARS1025, ARS at XI-1, ARS at XI-8, ARS at XI-14, ARS at XII-822, ARS at XII-873, ARS at XIV-36, ARS at XIV-127, ARS at XIV-352, ARS at XVI-910, ARS215, ARS at IV-611, ARS at IV-973, ARS at IV-1211, ARS at V-563, ARS523, ARS at VII-338, ARS at VII-540, ARS722, ARS at VII-576, ARS at VII-582, ARS at VII-743, ARS912, ARS at IX-183, ARS at , ARS at IX-238, ARS at XI-530, ARS at XII-638, ARS1233, ARS at XII-1020, ARS1234, ARS at XIV-656, ARS at XIV-764, ARS at XIV-773, ARS at XV-245, ARS1519, ARS at XVI-262, ARS at XVI-584, ARS at , ARS107, ARS at II-246, ARS at II-366, ARS309, ARS at IV-220, ARS711, ARS at VII-270, ARS at IX-81, ARS1208, ARS1209, ARS1211.5, ARS at XIII-112, ARS1307.5, ARS at XIII-227, ARS at II-78, ARS at II-129, ARS207, ARS207.1, ARS215.5, ARS at II-504, ARS221, ARS at II-695, ARS415, ARS at IV-879, ARS442, ARS at IV-1469, ARS at IV-1471, ARS at V-510, ARS at VII-26, ARS at , ARS at VII-805, ARS at VII-863, ARS at VII-1063, ARS at VIII-198, ARS at VIII-342, ARS at , ARS at XI-141, ARS at XII-12, ARS at , ARS1235, ARS at XIII-313, ARS1320, ARS at XIII-879, ARS at , ARS at XV-309, ARS at XV-521, ARS1604, ARS at XVI-57, ARS1620.5. |
Activation ('firing') efficiency determined: |
None curated. |
Analysed by microarray: |
ARS102.5, ARS at I-102, ARS108, ARS at I-166, ARS at I-172, ARS110, ARS202, ARS207.5, ARS at II-229, ARS211, ARS216, ARS at II-551, ARS220, ARS223, ARS at II-732, ARS225, ARS227, ARS305, ARS306, ARS at III-85, ARS307, ARS308, ARS310, ARS at III-193, ARS313, ARS314, ARS at , ARS314.5, ARS at III-224, ARS315, ARS316, ARS404, ARS406, ARS409.5, ARS413, ARS416, ARS417, ARS418, ARS420, ARS422, ARS422.5, ARS423, ARS at IV-865, ARS428, ARS429, ARS430, ARS431, ARS431.5, ARS432, ARS at , ARS432.5, ARS433, ARS at , ARS435, ARS at IV-1306, ARS at IV-1380, ARS at IV-1385, ARS441, ARS at IV-1455, ARS446, ARS at , ARS at , ARS507, ARS508, ARS510, ARS511, ARS512, ARS at V-317, ARS516, ARS517, ARS518, ARS519, ARS520, ARS601, ARS601, ARS at , ARS603, ARS603.5, ARS604, ARS606, ARS607, ARS at VII-8, ARS at VII-17, ARS702, ARS at VII-70, ARS704, ARS at VII-115, ARS706, ARS707, ARS at VII-167, ARS710, ARS714, ARS at VII-288, ARS716, ARS717, ARS718, ARS719, ARS721, ARS at VII-654, ARS727, ARS728, ARS729, ARS731, ARS731.5, ARS733, ARS805, ARS815, ARS at VIII-360, ARS at VIII-367, ARS at VIII-381, ARS at , ARS818, ARS820, ARS822, ARS at VIII-505, ARS823.5, ARS at IX-34, ARS907, ARS at , ARS909, ARS at IX-205, ARS913, ARS at IX-220, ARS at IX-283, ARS920, ARS at IX-363, ARS922, ARS1005, ARS1007, ARS1007.5, ARS1009, ARS1010, ARS at X-305, ARS1012, ARS1013, ARS1014, ARS1018, ARS1019, ARS1021, ARS1103, ARS1104.5, ARS at , ARS1106, ARS1106.7, ARS at XI-257, ARS at XI-302, ARS1113, ARS1114, ARS1114.5, ARS1116, ARS at XI-584, ARS1120, ARS at XI-617, ARS at XI-633, ARS1123, ARS at XII-31, ARS1206, ARS at XII-187, ARS1210, ARS1211, ARS1212, ARS at XII-294, ARS1213, ARS1215, ARS1217, ARS at XII-599, ARS1218, ARS at , ARS1220, ARS1223, ARS at XII-749, ARS1226, ARS1227.5, ARS at XII-928, ARS at XII-931, ARS at , ARS at XII-975, ARS1232, ARS1303, ARS1304, ARS1305, ARS1307, ARS1308, ARS1310, ARS at XIII-290, ARS1312, ARS at XIII-373, ARS at XIII-433, ARS1319, ARS1325, ARS1330, ARS1332, ARS1407, ARS at XIV-159, ARS at XIV-180, ARS1412, ARS at , ARS1414, ARS1415, ARS at XIV-325, ARS1417, ARS at XIV-417, ARS at XIV-459, ARS at XIV-516, ARS1422, ARS at XIV-568, ARS1424, ARS at XIV-617, ARS1427, ARS at , ARS at , ARS1509, ARS1510, ARS1510.5, ARS1511, ARS1513, ARS1513.5, ARS at XV-459, ARS at XV-464, ARS1514, ARS at XV-495, ARS1516, ARS at , ARS1517, ARS at XV-605, ARS at XV-737, ARS1523, ARS at XV-902, ARS1528, ARS at , ARS1529, ARS at XV-1011, ARS1529.5, ARS1605, ARS1607, ARS at XVI-191, ARS1614, ARS at XVI-332, ARS1618, ARS1618.5, ARS1619, ARS at XVI-423, ARS1621, ARS at XVI-553, ARS at XVI-560, ARS1622, ARS1622.5, ARS1623, ARS1624, ARS at XVI-691, ARS1625, ARS1626.5, ARS1627, ARS at XVI-873, ARS1631, ARS at , ARS at XVI-942, ARS106, ARS at , ARS at III-146, ARS405, ARS at , ARS at IV-167, ARS434, ARS at , ARS437, ARS at IV-1356, ARS522, ARS809, ARS at VIII-261, ARS at X-212, ARS1011, ARS1020, ARS1109, ARS at XII-71, ARS at XII-77, ARS at XIII-58, ARS1309, ARS1323, ARS at XIII-727, ARS1327, ARS at XIII-763, ARS at XIII-786, ARS at , ARS at XV-855, ARS1601, ARS1602, ARS at XVI-19, ARS at XVI-91, ARS at XVI-179, ARS at , ARS1609, ARS at XVI-215, ARS203, ARS at II-96, ARS at II-100, ARS214, ARS221.5, ARS at V-256, ARS734, ARS at VII-1002, ARS at VIII-116, ARS813, ARS1008, ARS1112, ARS at XII-140, ARS1316, ARS at XIII-478, ARS1508, ARS at XV-699, ARS425, ARS at V-302, ARS605, ARS at VIII-403, ARS1004, ARS1017.5, ARS at XII-434, ARS at XVI-440, ARS105, ARS228, ARS at , ARS229, ARS409, ARS414, ARS417.5, ARS at IV-791, ARS at IV-820, ARS at IV-1524, ARS807, ARS at VIII-135, ARS at , ARS810, ARS at VIII-219, ARS at , ARS916, ARS at IX-314, ARS at XII-856, ARS1413, ARS1526, ARS at XV-947, ARS at , ARS at XVI-163, ARS at XVI-489, ARS1628, ARS at , ARS at III-308, ARS at IV-739, ARS600.3, ARS600.4, ARS at VI-236, ARS at VIII-46, ARS1016, ARS1017, ARS at X-485, ARS1022, ARS at , ARS1024, ARS1025, ARS at XI-1, ARS at XI-8, ARS at XI-14, ARS at XII-822, ARS at XII-873, ARS at XIV-36, ARS at XIV-127, ARS at XIV-352, ARS at XVI-910, ARS215, ARS at IV-611, ARS at IV-973, ARS at IV-1211, ARS at V-563, ARS523, ARS at VII-338, ARS at VII-540, ARS722, ARS at VII-576, ARS at VII-582, ARS at VII-743, ARS912, ARS at IX-183, ARS at , ARS at IX-238, ARS at XI-530, ARS at XII-638, ARS1233, ARS at XII-1020, ARS1234, ARS at XIV-656, ARS at XIV-764, ARS at XIV-773, ARS at XV-245, ARS1519, ARS at XVI-262, ARS at XVI-584, ARS at , ARS107, ARS at II-246, ARS at II-366, ARS309, ARS at IV-220, ARS711, ARS at VII-270, ARS at IX-81, ARS1208, ARS1209, ARS1211.5, ARS at XIII-112, ARS1307.5, ARS at XIII-227, ARS at II-78, ARS at II-129, ARS207, ARS207.1, ARS215.5, ARS at II-504, ARS221, ARS at II-695, ARS415, ARS at IV-879, ARS442, ARS at IV-1469, ARS at IV-1471, ARS at V-510, ARS at VII-26, ARS at , ARS at VII-805, ARS at VII-863, ARS at VII-1063, ARS at VIII-198, ARS at VIII-342, ARS at , ARS at XI-141, ARS at XII-12, ARS at , ARS1235, ARS at XIII-313, ARS1320, ARS at XIII-879, ARS at , ARS at XV-309, ARS at XV-521, ARS1604, ARS at XVI-57, ARS1620.5. |
Other analysis: |
None curated. |
The data on this page come directly from PubMed and OriDB databases, please report any errors to OriDB.
This page is new! Please let us know of any problems you experience.
|
